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A 1992 New England Journal of Medicine randomized trial found that prednisolone significantly improves short-term survival for severe, biopsy-proven alcoholic hepatitis, with a 28-day regimen showing an 88% survival rate compared to 45% for placebo. The study, targeting patients with high Maddrey Discriminant Function scores, established prednisolone as a key therapeutic intervention for the condition. Read the original study on nejm.org .

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