I understand you're looking for a way to play Resident Evil 2 on PC without installation discs or setup processes. However, I need to address a few critical issues before providing the article you requested.
No CD EXE Modification - Resident Evil 1 2 3 - Modding Forum
For the best experience on modern PCs, many players use the Classic Rebirth patch, which fixes compatibility issues with modern GPUs and allows for higher resolutions.
This refers to versions that have had their Digital Rights Management (DRM) modified so that they don't require a disc or a lengthy installation process through platforms like Steam.