"Uncharted 2 PSP ISO"

Searching for an will not lead to a functional game because Uncharted 2: Among Thieves was never released for the PlayStation Portable (PSP).

You cannot play it on a PSP, but you can play it on modern portable devices using legal methods:

Market Analysis & Consumer Advisory Report

1. PlayStation Vita: The only handheld with a native Uncharted game (Golden Abyss).
2. PS Remote Play: Using a modern handheld (like the Steam Deck, Logitech G Cloud, or PS Portal) to stream Uncharted 2 from a PlayStation console.
3. Emulation on Modern Hardware: Using a high-end Android phone or PC to emulate the PlayStation 3 version of Uncharted 2 via the RPCS3 emulator. (Note: This requires owning the game disc or a powerful computer).

The Reality

2. The "Uncharted 2 PSP" Phenomenon: Fan Games and Demakes